Process for making a biocompatible porous holllow fiber

Details Process for making a biocompatible porous holllow fiber Process for making a biocompatible porous holllow fiber

1997-06-18

1998-10-06

Tentoni, Leo B.

Plastic and nonmetallic article shaping or treating: processes

Direct application of electrical or wave energy to work

Producing or treating porous product

264 83, 264101, 264233, 264235, 264488, 427244, 427249, 427400, 427497, 427501, B29C 3508, D01F 9127, D01F 1100, D02G 300

Patent

active

058172726

ABSTRACT:
A process of making a biocampatible porous hollow fiber that is made of polyolefine material and is coated with a biocompatible carbon material is disclosed. The biocompatible hollow fiber produced can be used as exchange material, diaphragms and/or semipermeable membranes within devices which will contact blood or plasma outside of the living body. The coated fiber is produced by introducing a preformed porous hollow fiber into an atmosphere of gaseous monomer vinylidene chloride and subsequent induction, e.g. by gamma radiation, of a graft-polymerization reaction to form an uniform polyvinylidene chloride layer. The ultimate coating is formed after a dehydrochlorination reaction in which hydrogen chloride is removed from the layer. The dechlorination reaction is typically performed by treating the fiber with hot concentrated aqueous ammonia solution. The reaction can be continued to reduce the chlorine content of the coating to less than 6% of its original value.

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