Process for making 5-introbarbituric acid and salts thereof

Details Process for making 5-introbarbituric acid and salts thereof Process for making 5-introbarbituric acid and salts thereof

1994-01-10

1995-06-27

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23902

Patent

active

054281652

ABSTRACT:
A process for preparing salts of 5-nitrobarbituric acid involves allowing an in situ generated a compound represented by formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are, H, C.sub.1 to C.sub.8 alkyl or substituted C.sub.1 to C.sub.8 alkyl, aryl or substituted aryl, to condense with urea to obtain a condensation product; and neutralizing the condensation product with at least one organic base and another cation source (MX) at a pH.gtoreq.7 and recovering the thus formed salt of 5-nitrobarbituric acid.

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