Process for making 5-fluorouracil

Details Process for making 5-fluorouracil Process for making 5-fluorouracil

1981-05-18

1983-10-04

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424251, C07D23920

Patent

active

044080484

ABSTRACT:
A process for preparing 5-fluorouracil, and a novel starting compound for such process, are disclosed. The novel starting compound is 2,4,5-trifluoropyrimidine. The process comprises hydrolyzing the 2,4,5-trifluoropyrimidine at a temperature of about 2.degree. to about 100.degree. C., thereby directly producing the compound 5-fluorouracil.
5-Fluorouracil is a known anti-tumor agent, which has been used in the treatment of various types of cancers. In addition, 5-fluorouracil is a starting material for the production of certain types of pro-drugs, which are metabolized to form 5-fluorouracil in the body, such as, for instance, the compound 1-(2-tetrahydrofuryl)-5-fluorouracil.

REFERENCES:
patent: 3682917 (1972-08-01), Knuniants et al.
patent: 4122251 (1978-10-01), Misaki et al.
patent: 4186266 (1980-01-01), Yamazaki et al.
Brown, The Pyrimidines, pp. 148-149 (1970) (Wiley-Interscience).

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