Process for making 2-amino-2-imidazoline, guanidine and 2-amino-

Details Process for making 2-amino-2-imidazoline, guanidine and 2-amino- Process for making 2-amino-2-imidazoline, guanidine and 2-amino-

1997-11-25

2000-05-23

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483481, 5483491, 5483501, 5483511, 5483521, 544330, 564230, 564231, C07D22314, C07D22316, C07D22318, C07D22524

Patent

active

060667400

ABSTRACT:
The present invention provides a process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydroyrimidine derivatives by preparing the corresponding activated 2-thio-subsituted-2-derivative in a two-step, one-pot procedure and by further reacting yields this isolated derivative with the appropriate amine or its salts in the presence of a proton source. The present process allows for the preparation of 2-amino-2-imidazolines, quanidines, and 2-amino-3,4,5,6-tetrahydropyrimidines under reaction conditions that eliminate the need for lengthy, costly, or multiple low yielding steps, and highly toxic reactants. This process allows for improved yields and product purity and provides additional synthetic flexibility.

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