Process for making 1,3-dioxane derivatives

Details Process for making 1,3-dioxane derivatives Process for making 1,3-dioxane derivatives

1984-11-09

1988-02-02

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

564 99, 549373, 549375, C07C 5948, C07C14372

Patent

active

047230371

ABSTRACT:
The invention provides a novel process for making novel (4-phenyl-1,3,-dioxan-cis-5-yl)alkenoic acids of the formula I in which Ra and Rb are independently hydrogen, alkenyl, alkyl, halogenoalkyl, pentafluorophenyl, aryl or aryl-(1-4C)alkyl; or Ra and Rb together are polymethylene; Rc is hydroxy or (1-6C)alkanesulphonamido, A is vinylene, n is 1, Y is polymethylene, and benzene ring B bears various optional substituents. The process involves the reaction of an aldehyde of formula II with an ylid to give an erythro-diol of formula III which is then cyclized to the required dioxane derivative of formula I. The invention also provides a novel process for making the aldehydes of formula II from the corresponding lactols of formula IIa, which are themselves obtained with the correct trans-stereochemistry by two selective reductions of a trans-phenylparaconic acid of formula V. The compounds of formula I are useful as therapeutic agents.

REFERENCES:
patent: 4567197 (1986-01-01), Brewster
Bull. Soc. Chim. Japan, 1968, 41, 1468-1471, Takeda et al.
Impadoc Search Report of EP 94239-1/86.

Affiliated with

Also associated with

Rating

Process for making 1,3-dioxane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for making 1,3-dioxane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for making 1,3-dioxane derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1636748