Process for low chloride 1,2,4-triazol-5-one

Details Process for low chloride 1,2,4-triazol-5-one Process for low chloride 1,2,4-triazol-5-one

1989-05-01

1990-05-22

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D24912

Patent

active

049279408

ABSTRACT:
A process for producing 1,2,4-triazol-5-one reacts an aqueous hydrazine solution with urea to form a reaction mixture of semicarbazide and ammonia, the reaction mixture is concentrated and an aqueous solution of a mineral acid added to form a slurry of a salt of semicarbazide. A formic acid compound is admixed with the slurry, and the slurry heated to produce 1,2,4-triazol-5-one. The novel process results in the production of a semicarbazide salt in situ and eliminates a number of process steps required in processes of the prior art.

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Chem. Abst. 62;14437: Ann. Chem., 682, pp. 123-135 (1965)(Germany), "1,2,4-Triazol-5-Ones, V. Effect of Substituents on the Rate of Hydrolysis in Half-Concentrated Sulfuric Acid".
Chem. Abst. 65;705: Khim. Geterotsikl. Soedin., Akad. Nauk Latv. SSR, 1966 (1), pp. 110-116 (Russian), ".sup..DELTA.5 -1,2,4-Triazolin-3-One and Its Nitro and Amino Derivatives".
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