Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1995-05-25
1997-04-22
Housel, James C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530412, 530816, 530822, C07K 100, A23J 100, C07C24500
Patent
active
056230583
ABSTRACT:
An assay to confirm the presence of antibodies to T. cruzi in a test sample. The assay comprises detecting the presence of antibody to three T. cruzi antigens, Gp90, Gp 60/50 and LPPG in a test sample. The presence of antibody in the test sample to at least two of three T. cruzi antibodies is indicative of a confirmed reactive sample. Also provided are diagnostic reagents for detection of T. cruzi, a process for purifying GP 60/50, a process for linking a protein and LPPG, and diagnostic test kits for use when assaying for antibodies to T. cruzi.
REFERENCES:
G.A. Schmunis, et al., "Trypanosoma cruzi, The Etiological Agent of Chagas' Disease: Status in the Blood Supply in Endemic and Nonendemic Countries," Transfusion 31(6): 547-557 (1991).
Anonymous, "Control of Chagas Disease: Report of a WHO Expert Committe," WHO Technical Report Series 1991, 811:1-93 WHO, Geneva (1991).
S. Kingman, "South America Declares War on Chagas Disease," New Scientist 132:16-17 (19 Oct. 1991).
N.C. Woody, et al., "American Trypanomomiasis (Chagas' Disease): First Indigenous Case in the United States," JAMA 159(7):676-677 (1985).
R.J. Schiffler, et al., "Indigenous Chagas' Disease (American Trypanosomiasis) in California," J.A.M.A. 251(22):2983-2984 (1984).
J.D. Pearlman, "Chagas' Disease in Northern California," Am. J. Med. 75:1057-1060 (1983).
T.R. Navin, et al., "Human and Sylvatic Trypanosoma cruzi Infection in California," Am. J. Public Health 75(4):366-369 (1985).
L.V. Kirchhoff, et al., "Chagas' Disease in Latin American Immigrants," JAMA 254(21): 3058-3060 (1985).
L.V. Kirchhoff, et al., "American Trypanosomiasis (Chagas' Disease) in Central American Immigrants," Am. J. Med. 82(915-920) (1987).
A. Skolnick, "Deferral Aims to Deter Chagas' Parasite," JAMA 265(2):173 (Jan. , 1991).
P. Kerndt, et al., "Trypanosoma cruzi Antibody Among Blood Donors in Los Angeles, California," Transfusion 28 (Supplement):31S, Abstract No. S108 (1988).
P.R. Kerndt, et al., "Prevelance of Antibody to Trypanosoma cruzi Among Blood Donors in Los Angeles, California" Transfusion 31(9):814-818 (1991).
P.O. Pehrson, et al., "Asymopomatic Congential Chagas' Disease in a 5 Year Old Child," Scan. J. Inf. Dis. 13:307-308 (1981).
A. Skolnick, "Does Influx From Endemic Areas Mean More Transfusion-Associated Chages' Disease?" JAMA 262(11):1433 (1989).
P. Nickerson, et al., "Tranfusion-Associated Trypanosoma cruzi Infection in a non-endemic area," Ann. Int. Med. 111(10):851-853 (1989).
Anonymous, "Parasite T. cruzi in US Blood Supply?" Clinica No. 354:16 (Jun. 7, 1989).
L.V. Kirchhoff, "Is Trypanosoma cruzi a New Threat to Our Blood Supply?" Ann. Int. Med. 111(10):773-775 (1989).
G. Bonfirm, et al., "Detection of Antibodies to Trypansoma cruzi in Blood Donors," Abstracts of Inter. Soc. ofBlood Trans./Am. Assoc. Blood Banks Abstract No. S445, (Nov. 10-15, 1990).
I.H. Grant, et al., "Transfusion-Associated Acute Chagas Disease Acquired in the United States," Ann. Int. Med. 111(10):849-850 (1989).
M. Boxaca, et al., "HIV-1 Prevelance and the Role of Other Infection Diseases in a Group of Drug Users in Argentina," Track C: Epidemiology & Prevention, Int. Conf. AIDS Abstract No. 3141 (1991).
A.L. Bittencourt, "Congential Chagas Disease," Am. J. Dis. Child 130:97-103 (1976).
Hoff, et al., "Congential Chagas' Disease in an Urgan Population: Investigation of Infected Twins," Trans. Royal Soc. Trop. Med. and Hygeine 72(3): 247-250 (1978).
M.D. Gudino, et al., "Chagas' Disease and Blood Transfusion, in R.G. Westphal, et al., eds.," Emerging Global Patterns in Transfusion Transmitted Infections pp. 65-68 American Assoc. of Blood Banks, Arlington, VA (1990).
I.G. Kagan, et al., "Studies on Trypanosoma cruzi Isolated in the United States: A Review," Rev. Biol. Trop. 14(1):55-73 (1966).
J.C. P.Dias, et al., "Chagas' Disease and Blood Transfusion," Mem. Inst. Oswaldo Cruz, Rio de Janiero, Suppl. 79:139-147 (1984).
E.L. Segura, "Xenodiagnosis in Chagas' Disease Vectors," R.R. Brenner, et al., eds., II: 41-45, Boca Raton, FL, CRC Press (1987).
F. Zicker, et al., "Mass Screening for Trypanosoma cruzi Infections using the Immunofluorescence, ELISA and Haemagglutination Tests on Serum Samples and on Blood Eluates from Filter-Paper," Bull. of WHO 68(4):465-471 (1990).
M.E. Camargo, et al., "Three Years of Collaboration on the Standardization of Chagas' Disease Serodiagnosis in the America: An Appraisal," PAHO Bull. 20(3):233-244 (1986).
A.A. Pan, et al. "Clinical Evaluation of an EIA for the Sensitive and Specific Detction of Serum Antibody to Tryaonosoma cruzi (Chagas' Disease)," JID 165:585-588 (Mar. 1992).
A.W. Ferreira, et al., "Aspectos da padronizacai de testes solologicos para a doenca de chagas: um test imunoenzumatico para a triagem de doadores de sangue," Rev. Inst. Med. Trop. Sao Paulo 33(2):123-128 (1991).
D.E. Lanar, et al., "Complexity and Content of the DNA and RNA in Trypansoma Cruzi," Molec. and Biochem. Parasit. 3:337-341 (1981).
S.P. Craig, et al., "Trypanosoma (Schizotrypanum cruzi: Repetitive DNA Sequence Evolution in Three Geographically Distinct Isolates," Comp. Biochem. Physiol. 95B (4):657-662 (1990).
M. Schechter, et al., "Purified Trypanosoma cruzi Specific Glycoprotein for Distriminative Serological Diagnosis of South american Trypanosomiasis (Chagas' Disease)," Lanet 939-941 (Oct. 22, 1983).
L.V. Kirchhoff, et al., "Increased Specificity of Serodiagnosis of Chagas' Disease by Detection of Antibody to the 72- and 90-kilodalton Glycoproteins of Trypansoma cruzi," JID 155(3): 561-564 (1987).
J.O. Previato, et al., "Primary Structure of the Oligosaccharide Chain of Lipopeptidophosphoglycan of Epimastigote Forms of Trypanosoma cruzi," J. Biol. Chem. 265(5):2518-2526 (1990).
C.T. Pat, "Cultivation of the Lesihmaniform Stage pf Trypanosoma cruzi cell freemedia at Different Temperatures," Am. J. Trop. Med. and Hygiene 17(6):823-832 (1968).
P.M. Rainey, et al. "Biochemical and Molecular Characterization of Leishmania pifanoi amastigotes in Continuous Axenic Culture," Molec. and Biochem Parasit. 49:111-118 (1991).
S.C. Pan, "Establishment of Clone of Trypanosoma cruzi and Their Characterization in vitro and in vivo," Bull. of WHO 60(1):101-107 (1982).
A.A. Pan, et al., "Anastigote and Epimastigote State-Specific Components of Trypanosoma cruzi Characterized by Using Monoclonal Antibodies," J. Immunol. 143:1001-1008 (1989).
M.A. Winkler, et al., "Catalytic Site of Calmodulin-dependent Protein Phosphatase From Bovine Brain Residues in Subunit A," Proc. Natl. Acad. Sci. USA 81:3054-3058 (1984).
U.K. Laemmli, "Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophase T4,"Nature 227:680-685 (Aug. 15, 1970).
S. Bauminger, et al., "The Use ofCarbodiimides in the Preparation of Immunizing Conjugates," Methods in Enzyme 70:151-159 (1980).
W.M. Hunter, et al., "Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity," Nature 194:495-496 (May 5, 1962).
R.C.K. Wong, et al., "Immune Precipitation and Immunoblotting For The Dection of Trypanosoma cruzi Antigens," Trans. Royal Soc. Trop. Med. and Hygiene 80:275-281 (1986).
M. Gottlieb, "A Carbohydrate-Containing Antigen from Trypansoma cruzi and its Detection in the Circulation of Infected Mice," J. of Immunol. 119(2):465-470 (1977).
F. Zicker, et al., "Trends of T. cruzi Infection Based on Data From Blood Bank Screening," Rev. Inst. Med. Trop. Sao Paulo 32(2):132-137 (1990).
M.E. Camargo, et al., "Hemagglutination With Preserved, Sensitized Cells, a Practical Test For Routine Serologica Diagnosis of American Trypanosomaisis," Rev. Inst. Med. Trop. Sao Paulo 15(2):81-85 (1973).
M.E. Camargo, et al., "Cross-Reactivity in Fluorescence Tests for Trypanosoma and Leishmania Antibodies," Am. J. Trop. Med. and Hygiene 18(4):500-505 (1969).
M. Schechter, et al., "Further Evaluation of Lectin Affinity Purified Glycoprotein (GP90) in the Enzyme Linked Immunoaborbant Assay (ELISA) for Diagnosis of Trypansoma Cruzi Infection," Trans. Royal Soc. Trop. Med. and Hygiene 79:637-640 (1985).
G.A. Schmunis, et al., "Anti-Trypanosoma cruzi Agglutination in Acute Hu
Pan Alfred A.
Winkler Martin A.
Abbott Laboratories
Becker Cheryl L.
Housel James C.
Porembski Priscilla E.
Shaver Jennifer
LandOfFree
Process for linking an antigenic glycolipid of T. cruzi to a pro does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for linking an antigenic glycolipid of T. cruzi to a pro, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for linking an antigenic glycolipid of T. cruzi to a pro will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-342643