Process for labelling sulfur-containing compounds

Details Process for labelling sulfur-containing compounds Process for labelling sulfur-containing compounds

1987-10-28

1990-02-13

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

346 16, 346 17, 549 30, 549 40, 540466, 540543, 548409, 548950, 548958, C07D49510, C07D49710

Patent

active

049008307

ABSTRACT:
The invention thus provides a process for obtaining the preferential replacement by isotopes, of at least one of the hydrogen atoms selected from the group consisting of those attached to the .alpha.- or .alpha.'-carbon atoms in a compound containing the structural moiety (I) ##STR1## which comprises the steps of oxidizing the compound to the corresponding sulfoxide or sulfone which contains the corresponding structural moiety (II) ##STR2## wherein in the sulfoxide n is 1 and in the sulfone n is 2, effecting the isotopic replacement by a known method of said at least one hydrogen atom, and reducing the resultant isotope-labelled sulfoxide or sulfone to the correspondingly labelled compound containing the structural moiety (I).

REFERENCES:
March, "Advanced Organic Chemistry", 3rd Edition (1985), (McGraw-Hill), pp. 1108 and 1089-1080.

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