Process for L-dopa

Details Process for L-dopa Process for L-dopa

1986-08-22

1987-12-29

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562401, C07C 9908

Patent

active

047162465

ABSTRACT:
A process for the preparation of (S)- or L-3-(3,4-dihydroxyphenyl)alanine (L-dopa) is described. The process utilizes water as reaction process solvent and proceeds via formation of an intermediate which can be kinetically resolved in a polar solvent to a precursor of the desired isomer and in which the undesired isomer can be efficiently racemized for reuse.

REFERENCES:
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patent: 4005127 (1977-01-01), Knowles et al.
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patent: 4436910 (1984-03-01), Kleemann et al.
Kaigorodova et al, Isvestiya Okal Nauk SSSR, vol. 5, pp. 1001-1004 (1984).
Secor, Chem. Review, 80, pp. 297-308.

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