Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen bonded directly to ring carbon of the purine ring...
Patent
1995-05-30
1997-11-18
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen bonded directly to ring carbon of the purine ring...
544264, 544265, 544 71, 544277, C07D47318, C07D47316, C07D47306, C07D47330
Patent
active
056889488
ABSTRACT:
Herein is disclosed a novel and industrially advantageous process for synthesizing acyclic nucleosides such as acyclovir and ganciclovir from ribonucleosides, which process comprises adding an acid catalyst and an acid anhydride to a solution of a ribonucleoside such as guanosine and an ester derivative of an acyclic sugar, and heating the mixture, whereby a transglycosilation reaction takes place between the ribose moiety of the ribonucleoside and the ester derivative of the acyclic sugar.
Herein is also disclosed an industrially favorable method for the separation of 9-substituted purine nucleosides which are important intermediates for the synthesis of acyclic nucleosides such as acyclovir, ganciclovir, and the like from ribonucleosides, which method comprises crystallizing only the 9-isomer from a solution or suspension containing both a 9-substituted purine nucleoside and a 7-substituted purine nucleoside by cooling the solution or/and by adding a crystallizing solvent thereto.
REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
patent: 5336770 (1994-08-01), Shiragami et al.
Martin et al, J Med Chem 26, 759(1983).
Ogilvie, Can J Chem 62, 2702 (1984).
Boryski, Nucleosides & Nucleotides 6, 385(1987).
Boryski Nucleosides & Nucleotides 8, 529(1989).
Izawa Kunisuke
Koguchi Yoshihito
Shiragami Hiroshi
Takamatsu Satoshi
Uchida Yumiko
Ajinomoto Co. Inc.
Berch Mark L.
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