Process for isolation of hepatoprotective agent...

Details Process for isolation of hepatoprotective agent... Process for isolation of hepatoprotective agent...

2005-04-26

2005-04-26

Tsang, Cecilia J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

06884908

ABSTRACT:
Accordingly the present invention provides an improved and economical process for the isolation of oleanolic acid from the roots ofLantana camara, which comprises of drying, grinding and defattening ofLantana camararoots with light petroleum followed by over night extractions at room temperature (30-40° C.) three times with a single solvent selected from CH2Cl2, CHCl3, EtOAc, ether, acetone, MeOH, EtOH etc., removal of solvent under vacuum at 35-45° C., precipitation of crude extract and repeated partial crystallization of precipitate with a single solvent selected from CH2Cl2, CHCl3, EtOAc, ether, acetone, MeOH, EtOH, H2O and others resulting in the isolation of oleanolic acid with 1% yield.

REFERENCES:
Misra et al , High concentration of hepatoprotective oleanolic acid and its derivatives in theLantana camararoots, Feb. 1997, Planta Medica, 63: p. 584.

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