Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-01-18
2010-12-28
Dentz, Bernard (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07858812
ABSTRACT:
The present invention relates to a simple and commercially viable process for separation of desired isomers of nebivolol intermediates from a mixture containing undesired isomers of nebivolol intermediates. Thus, (+)-[2R*[1S*,5S*(S*)]]+[2R*[1S*,5R*(R*)]]-α,α′-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] is dissolved in diisopropyl ether at reflux temperature and cooled to below about 30° C. to obtain the desired (+)-[2R*[1S*,5S*(S*)]]-α,α′-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol].
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H.Y. Aboul-Enein and I. Ali, HPLC Enantiomeric Resolution of Nebivolol on Normal and Reversed Amylose Based Chiral Phases, Pharmaceutical Analysis Laboratory, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, (2001), 56(3), 214-216, Supplied by the British Library—The World's Knowledge.
PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration dated Jan. 18, 2006.
Muralidhara Reddy Dasari
Parthasaradhi Reddy Bandi
Raji Reddy Rapolu
Rathnakar Reddy Kura
Srinivas Reddy Itiyala
Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd
Dentz Bernard
Hetero Drugs Limited
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