Process for isolation and radiolabeling of pharmaceuticals with

Details Process for isolation and radiolabeling of pharmaceuticals with Process for isolation and radiolabeling of pharmaceuticals with

1989-12-29

1992-04-07

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

423249, A61K 4300

Patent

active

051026511

ABSTRACT:
A process for recovering At-211 from a target and simultaneously producing an At-211-labeled radiopharmaceutical agent involves introducing volatilized At-211, produced by dry distillation of an irradiated Bi-209 target, into a solution containing a compound that binds the At-211 to form an At-211-labeled radiopharmaceutical agent. The radiopharmaceutical agent may have therapeutic use as is, or may be attached to a targeting protein such as an antibody prior to administation to a patient.

REFERENCES:
patent: 4681727 (1987-07-01), Mirzadeh et al.
patent: 4826672 (1989-05-01), Milius et al.
patent: 4870188 (1989-09-01), Wilbur et al.
patent: 4876081 (1989-10-01), Wilbur et al.
patent: 4885153 (1989-12-01), Wilbur et al.
patent: 4894218 (1990-01-01), Engelstad et al.
Wilbur et al., Radiochimica Acta, 47, 137-142, (1989), "Reactions of Organometallic Compounds with Astatine-211, Application to Protein Labeling".
Shiue, C.-Y., and Wolf, A. P., Journal of Labelled Compounds and Radiopharmaceuticals, vol. XVIII, No. 7, pp. 1059-1066, "Synthesis of 4-fluoro-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one (4-fluoroantipyrine) and .sup.18 F-Labeled analog by direct fluorination of antipyrine with molecular fluorine".

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