Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-10-01
1987-06-09
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D51302
Patent
active
046721266
ABSTRACT:
A process for isolating levamisole or a therapeutically acceptable acid addition salt thereof from tetramisole or an acid addition salt thereof by precipitating levamisole. L-N-[(4-methoxyphenyl)sulfonyl]-glutamic acid (salt) and converting the diastereomeric salt into levamisole or a suitable acid addition salt thereof.
REFERENCES:
patent: 3579530 (1971-05-01), Dewar et al.
patent: 3580923 (1971-05-01), Leigh et al.
Bhatt et al. "Preparation and Antimicrobial Activity of L[+].alpha.-Arylsulphonamido Succinic Acids and L[+]-Disodium-.alpha.-Aryl-sulphonamido Glutarates", Indian Chem. Journal, Sep. 1978, pp. 21-22.
Guns Eric J.
Van der Veken Guido J. L.
Willemsens Albert L. A.
Daus Donald G.
Dellenbaugh Geoffrey
Janssen Pharmaceutica N.V.
Kapner Stephen M.
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