Process for isolating genes and the gene causative of Huntington

Details Process for isolating genes and the gene causative of Huntington Process for isolating genes and the gene causative of Huntington

1993-09-24

1996-07-09

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Vector, per se

536 235, 536 243, 536 2431, C12N 1512, C12N 1563

Patent

active

055344380

ABSTRACT:
The underlying genetic defect of Huntington disease (HD) has been mapped to chromosomal band 4.sub.p 16.3. Refined localization using recombinant HD chromosome analysis and allelic association analyses have identified two distinct candidate regions. Using a cDNA hybrid selection procedure, .alpha.-adducin has been mapped to the proximal 2.2 Mb 4D gene candidate region within 20 kb of D4S95. Several clones have been mapped within the minimal region containing the HD gene. The clones GT 70 and GT 149 are particularly useful in detecting changes in this portion of the gene of HD patients.

REFERENCES:
MacDonald, M. E., et al. (1993) Cell 72, 971-983.
Hutchinson, G. B., et al. (1993) Nuc. Acids Res. 21(15), 3379-3383.
Goldberg, Y. P., et al. (1993) Nature 362, 370-373.
Goldberg, Y. P., et al, (1992) Hum. Mol. Genet. 1(9), 669-675.
Snell, R. G., et al. (1993) Hum. Mol. Genet. 2(3), 305-309.
Buckler, A. J., et al. (1991) Prod. Natl. Acad. Sci. USA 88, 4005-4009.
MacDonald, M. E., et al. (1991) Am. J. Hum. Genet. 49, 723-734.
J. M. Rommens et al.; "A Transcription Map of the Region Containing the Huntington Disease Gene", Human Molecular Genetics; 1993 vol. 2, No. 7, pp. 901-907.
Alan B. Sachs, "Messenger RNA Degradation in Eukaryotes", Cell; 74:413-421 (1993).

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