Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-08-27
1992-06-09
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540523, 540530, 540485, 564151, A61K 31395, C07J 5100
Patent
active
051208474
ABSTRACT:
A novel, facile, and specific process for .alpha.-iodinating or .alpha.-brominating the .alpha.-methylenic carbon of a straight chain, branched chain, or cyclic secondary amide, such as a lactam or an azasteroid, comprises reacting the amide with trialkylsilyl-X (R.sub.3 Si--X), where X is Br, I, or Cl, and R is methyl, ethyl, or n-propyl, in the presence of I.sub.2 or Br.sub.2. The .alpha.-iodo- or .alpha.-bromo-amide is useful for making the .alpha.,.beta.-unsaturated amide through dehydrohalogenation.
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Abramson Newton L.
Anderson Kevin
Karady Sandor
King Anthony O.
Shuman Richard F.
Bencen Gerard H.
Caruso Charles M.
Merck & Co. , Inc.
Nicholson William H.
Rizzo Nicholas S.
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