Process for inverting the configuration of optically active comp

Details Process for inverting the configuration of optically active comp Process for inverting the configuration of optically active comp

1986-05-27

1990-08-28

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

548239, 564304, 564349, C07C 8200, C07D26312

Patent

active

049527304

ABSTRACT:
The invention relates to a process for inverting the configuration at the optically active carbon atom (*) in compounds of the formula I ##STR1## in which A denotes a carbocyclic or heterocyclic aromatic radical and R denotes an aliphatic, cycloaliphatic or araliphatic hydrocarbon radical, by formylation, treating the resulting compounds with a strong acid or an acid halide and cleaving the oxazolinium derivatives thus obtained, by acid or alkaline hydrolysis, if appropriate via the stage of the N-formyl compound, and to oxazolinium derivatives of the formula III defined herein and formed as intermediate products.

REFERENCES:
patent: 2446192 (1948-08-01), Pfister et al.
patent: 2513346 (1950-07-01), Moersch et al.
patent: 2530627 (1950-11-01), Pfister et al.
patent: 4237304 (1980-12-01), Dowd et al.
patent: 4391980 (1983-07-01), Zergenyi
Chem. Abs. 84 (7): 43593 x (1976)-Abstract of Japanese Patent 74 75,545 to Muro et al., for Inverting Steric Configurations of Aminoalcohols.

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