Process for introducing a thiocarboxylic ester group at the orth

Details Process for introducing a thiocarboxylic ester group at the orth Process for introducing a thiocarboxylic ester group at the orth

1987-11-05

1989-08-15

Garvin, Patrick P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544 35, 558250, 558252, 558257, 546244, 548530, 549513, C07D24136, C07D47100, C07D48700, C07D21156

Patent

active

048576450

ABSTRACT:
A process for introducing thiocarboxylic ester at ortho-position of phenols or phenylamines which comprises reacting a phenyl compound having group or optionally substituted amino or cyclic amino group, of which at least one ortho-position is vacant, with C.sub.1 -C.sub.5 alkyl thiocyanate, C.sub.7 -C.sub.13 aralkyl thiocyanate or C.sub.6 -C.sub.12 aryl thiocyanate in the presence of a boron trihalide and hydrolyzing the resultant product under acidic conditions is provided, and said process is useful in the synthesis of medicinals, pesticides and dyes.

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W. Theilheimer: "Synthetic Methods of Organic Chemistry", vol. 27, 1973, p. 273, S. Karger, Basel, CH, p. 273, par. 597.
Journal of the American Chemical Society, vol. 45, July 1923, pgs. 1744-1752, R. J. Kaufmann et al.; "Production of Imido Thiol Esters by the Condensation of Thiocyanates with Resorcinol or Phloroglucinol", pgs. 1744-1745.

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