Process for intermediates for the synthesis of LHRH antagonists

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence

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530328, 530330, 530331, 530338, 530339, 530333, 562562, 562571, A61K 3804, C07K 400, C07K 102

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active

057102465

ABSTRACT:
A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

REFERENCES:
patent: 5110904 (1992-05-01), Haviv et al.
patent: 5502035 (1996-03-01), Haviv et al.
Methods Neurosciences, vol. 13 (1993), pp. 3-18, F. Haviv et al., "Synthetic Approach to Incorporation of Novel Amino Acids into Gonadotropin Releasing Hormone Peptides".
Int. J. Peptide Protein Research, vol. 41, No. 4 (1993), pp. 342-346, H. B. Arzeno et al., "Temporary Serine Protection in Solid Phase Synthesis of LHRH Analogs".
J. Peptide Science, vol. 1, No. 2 (1995), pp. 89-105, G. A. Fluoret, e t al., "Antiovulatory Antagonists of LHRH Related to Antide".

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