Process for inhibiting platelet aggregation

Details Process for inhibiting platelet aggregation Process for inhibiting platelet aggregation

1977-03-07

1978-08-29

Goldberg, Jerome D.

Textiles: fiber preparation

424101, 424308, C12B 300, C12B 900, A61K 3514, A61K 31235

Patent

active

041101618

ABSTRACT:
A process for inhibiting platelet aggregation by the addition of a member selected from the group consisting of a compound of the formula: ##STR1## wherein Y is lower alkyl of 1 to 8 carbon atoms, cyclopropyl, ethinyl, -CF.sub.3, -F, -Cl, -OCH.sub.3, -OCHF.sub.3, -OCH.sub.2 OCH.sub.3, -SCH.sub.3, -SCHF.sub.2, -SCH.sub.2 OCH.sub.3, acetyl; R.sub.1 and R.sub.2 are H, CH.sub.3, CHF.sub.2, or taken together are .dbd.CH.sub.2 or .dbd.CF.sub.2 ; and X is hydrogen, lower alkyl of 1 to 8 carbon atoms or a pharmacologically acceptable cation, to in vivo and in vitro platelet systems. In vitro systems include whole blood as kept in blood banks, whole blood as used in heart-lung machines, and platelet rich concentrates. In vivo systems include human or animal bodies. The process provides a means for treating hemorrhage due to thrombocytopenia which in turn is caused by irradiation, cancer chemotherapy, or immunosuppressants as well as hemophilia due to congenital defects.

REFERENCES:
chemical Abstracts 71:91162(j) (1969).
Chemical Abstracts 74:99717(b) (1971).

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