Process for inhibiting platelet aggregation

Details Process for inhibiting platelet aggregation Process for inhibiting platelet aggregation

1974-12-06

1976-12-07

Goldberg, Jerome D.

Textiles: fiber preparation

C12B 300

Patent

active

039961036

ABSTRACT:
A process for inhibiting platelet aggregation by the addition of a member selected from the group consisting of a compound of the formula: ##SPC1##
Wherein is cyclohexane or phenyl; Y is hydrogen, halogen, --CF.sub.3, --OH, lower alkyl of 1 to 8 carbon atoms, lower alkoxy of 1 to 8 carbon atoms, --CN, --NH.sub.2, --SH, or --S-lower alkyl of 1 to 8 carbon atoms; and R is hydrogen, lower alkyl of 1 to 8 carbon atoms, inclusive, or a pharmacologically acceptable cation, to in vivo and in vitro platelet systems. In vitro systems include whole blood as kept in blood banks, whole blood as used in heart-lung machines, and platelet-rich concentrates. In vivo systems include human or animal bodies. The process provides a means for treating hemorrhage due to thrombocytopenia which in turn is caused by irradiation, cancer chemotherapy, or immunosuppressants as well as hemophilia due to congenital defects.

REFERENCES:
patent: 3644479 (1972-02-01), Judy et al.
patent: 3663627 (1972-05-01), Judy et al.

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