Process for inhibiting peptide carbamylation

Details Process for inhibiting peptide carbamylation Process for inhibiting peptide carbamylation

1984-08-08

1986-08-12

Waddell, Frederick E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

C07K 740

Patent

active

046055134

ABSTRACT:
There is disclosed herein a process for inhibiting carbamylation of peptides during treatment of said peptides, which comprises carrying out said treatment in the presence of a carbamylation-inhibiting amount of an agent selected from the group consisting of 1,2-ethylene diamine and 1,2-ethylene diamine-like materials.

REFERENCES:
G. R. Stark, W. H. Stein, S. Moore (1960), J. Biol. Chem. 235, 3177-3181.
R. D. Cole (1961), J. Biol. Chem., 236, 2670-2671.
G. R. Stark (1965), Biochem., 4, 1030-1036.

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