Process for induction culture of cytotoxic T lymphocytes having

Details Process for induction culture of cytotoxic T lymphocytes having Process for induction culture of cytotoxic T lymphocytes having

1995-06-20

1999-02-23

Woodward, Michael P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435373, 435383, 435325, 424 9371, 424534, C12N 508, C12N 500, A61K 3514

Patent

active

058743073

ABSTRACT:
A process for an induction culture of a cytotoxic T lymphocyte having cell killing activities against a tumor cell which comprises the step of coculturing a tumor tissue containing said tumor cell and a lymphocyte of autologous peripheral blood obtained from a subject from which the tumor tissue is derived. The process is convenient since no separation and pure culture of tumor cells is required. The resulting cytotoxic T lymphocyte cells are useful for clinical treatments of tumors, e.g. adoptive immunotherapies.

REFERENCES:
Kawai et al., Cancer Immunol. immunother (1992) 35:225-239, "Additive Effects of Antitumor Drugs and Lymphokine-Activated Killer Cell Cytotoxic Activity in Tumor Cell Killing Determined By Lactate-Dehydrogenase-Release Assay".
Biotherapy 4 (3) : 427-433, 1990.
Naito et al. 1981 Cell Biology International Reports 5 (7) pp. 675-681, Jul. 1981.
Rosenberg et al. 1986 Science 233 pp. 1318-1321, Sep. 19, 1986.
Mukherji et al 1990 Immunological Reviews 116 pp. 33-62, Aug. 1, 1990.
Hayashi et al. 1992 Cancer Immunology and Immunotherapy 34 pp. 419-423, Jan. 1, 1992.
Usuda et al 1993 J Gastroenterology and hepatology 8 pp. 517-523, Jan. 1, 1993.
Liu et al 1995 Nature Medicine 1 (3) 267-271, Mar. 1, 1995.

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