Process for inducing analgesia, peptides and therapeutic composi

Details Process for inducing analgesia, peptides and therapeutic composi Process for inducing analgesia, peptides and therapeutic composi

1991-11-01

1995-06-20

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 530324, 530326, 530327, 530300, A61K 3800, C07K 500, C07K 700, C07K 1400

Patent

active

054260990

ABSTRACT:
Peptides having two or more amino acid residues in the sequence of the amino acid residues of vasoactive intestinal peptide (VIP) segment 11-28, analogs and derivatives thereof and pharmaceutically acceptable salts thereof are provided which are characterized by inducing analgesia by delivery to the central nervous system when administered to a mammal. Also provided is a method of inducing analgesia by delivery to the central nervous system using direct or indirect routes to administer VIP peptide segment 11-28, peptides having two or more amino acids of sequence of the VIP peptide segment, analogs and derivatives thereof and pharmaceutically acceptable salts thereof. Additionally are provided analgesic pharmaceutical compositions of said peptides, analogs and derivatives thereof or pharmaceutical salts thereof and a pharmaceutically acceptable carrier therefore.

REFERENCES:
patent: 4237046 (1980-12-01), Podanszky
Komisaruk et al., Annal.-New York Academy of Science, v. 527, 1988, pp. 650-654.

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