Process for in vivo transfer of cell-mediated immunity in mammal

Details Process for in vivo transfer of cell-mediated immunity in mammal Process for in vivo transfer of cell-mediated immunity in mammal

1978-08-17

1979-12-25

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Destruction of hazardous or toxic waste

435272, 424 88, 424 95, C07G 700, A61K 3900

Patent

active

041806271

ABSTRACT:
Precipitates soluble in aqueous solution and suitable for stimulation and/or transfer of cell-mediated immunity in mammals and other animals is disclosed together with a solvent extraction process for obtaining this desirable product from crude bovine transfer factor. Lymphocytes from lymph nodes and blood of donor cattle are employed in formulating a Bovine Transfer factor by incubation release procedure. The fractionation of Bovine Transfer factor yields three precipitate fractions by the use of organic solvents. A relatively high incidence of transfer with the precipitates yields excellent immunity to certain diseases in animals.

REFERENCES:
Lawrence, Journal of Clinical Investigation, vol. 34, pp. 219-230 (1955).
Lawrence, in "Transfer Factor: Basic Properties and Clinical Applications", pp. 741-753 (1976), Ascher, et al., editors.
Klesius, et al., in Transplantation Proceedings, vol. VII (3), pp. 449-452, (1975).
Klesius, et al., in Clinical Immunology and Immunopathology, vol. 7, pp. 240-252 (1977).
Klesius, et al., in "Transfer Factor: Basic Properties and Clinical Applications", pp. 311-322 (1976).

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