Process for improving mass transfer in a membrane bioreactor and

Details Process for improving mass transfer in a membrane bioreactor and Process for improving mass transfer in a membrane bioreactor and

1990-10-11

1993-04-13

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352401, 435240241, 43524025, 435300, C12N 500, C12N 502, C12M 118

Patent

active

052022544

ABSTRACT:
A process for improving mass transfer in a bioreactor having at least one semi-permeable membrane defining first and second chambers on opposite sides of the membrane provides for circulating a first media including nutrients and the like through the first chamber and for circulating a second media for cell culture through the second chamber of the bioreactor. The first and second media may be circulated through a plurality of bioreactors connected in parallel while balancing the flow in each reactor. The flow in the second circuit can be periodically reversed to provide increased cell culture.

REFERENCES:
patent: 4680267 (1987-07-01), Eppstein
patent: 4889812 (1989-12-01), Guinn et al.
patent: 4937194 (1990-06-01), Pattillo
Tharakan et al Biotechnology and Bioengineering vol. XVII pp. 329-342 (1986).
Robertson et al Biotechnology and Bioengineering vol. XXVII pp. 1012-1020 (1985).

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