Process for improving flow characteristics of crystalline ibupro

Details Process for improving flow characteristics of crystalline ibupro Process for improving flow characteristics of crystalline ibupro

1993-09-03

1998-12-01

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562494, C07C 5142

Patent

active

058438637

ABSTRACT:
A process for producing crystalline ibuprofen having a crystal habit characterized by a particle length larger than 75 microns average and a length to width aspect ratio of greater than about 4 to 1 to about 5 to 1. The process involves crystallizing ibuprofen from a saturated solution of ibuprofen in a liquid hydrocarbon solvent by seeding and cooling such solution to a temperature of about 0.degree. C. to about -20.degree. C. at a rate to retard primary nucleation and promote secondary nucleation. The crystalline ibuprofen is separated from the slurry produced from such cooling.

REFERENCES:
patent: 4476248 (1984-10-01), Gordon et al.

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