Process for improving flow characteristics of crystalline ibupro

Details Process for improving flow characteristics of crystalline ibupro Process for improving flow characteristics of crystalline ibupro

1992-10-20

1994-10-04

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562493, C07C 5143, C07C 5142

Patent

active

053528239

ABSTRACT:
A process for producing crystalline ibuprofen having a crystal habit characterized by a particle length larger than 75 microns average and a length to width aspect ratio of greater than about 4 to 1 to about 5 to 1. The process involves crystallizing ibuprofen from a saturated solution of ibuprofen in a liquid hydrocarbon solvent by seeding and cooling such solution to a temperature of about 0.degree. C. to about -20.degree. C. at a rate to retard primary nucleation and promote secondary nucleation. The crystalline ibuprofen is separated from the slurry produced from such cooling.

REFERENCES:
patent: 4107439 (1978-08-01), Walker et al.
patent: 4135051 (1979-01-01), Walker
patent: 4476248 (1984-10-01), Gordon et al.
patent: 4582577 (1986-04-01), Wagenknecht
patent: 4948805 (1990-08-01), Ziggiotti et al.

Affiliated with

Also associated with

Rating

Process for improving flow characteristics of crystalline ibupro does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for improving flow characteristics of crystalline ibupro, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for improving flow characteristics of crystalline ibupro will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-582689