Process for identifying RAR-receptor-antagonist compounds

Details Process for identifying RAR-receptor-antagonist compounds Process for identifying RAR-receptor-antagonist compounds

1996-06-19

1998-10-27

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

514167, 514557, 514568, 514570, 436 2, G01N 3100, A61K 3159, A61K 3119

Patent

active

058275002

ABSTRACT:
The present invention relates to a process for identifying RAR-antagonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of an RAR-agonist molecule is applied topically to a part of the skin of a mammal, (ii) a molecule capable of having an RAR-antagonist activity is administered systemically or topically to this same mammal, or to this same part of the skin of the mammal, before, during or after step (i), and (iii) the response on that part of the skin of the mammal thus treated is evaluated.

REFERENCES:
patent: 4889847 (1989-12-01), Kligman
patent: 4992468 (1991-02-01), Chandraratna
patent: 5091518 (1992-02-01), Sucov et al.
patent: 5141959 (1992-08-01), Carroll et al.
patent: 5612356 (1997-03-01), Yoshimura et al.
patent: 5658949 (1997-08-01), Aggarwal
Chandraratna et al., Abstract 242 for 1996 Annual Meeting of Investigative Dermatology, J. Invest. Derm., 106(4), p. 846, Apr. 1996.
Eckhardt et al., Toxicol. Let., 70, pp. 299-308, Feb. 1994.
Giendimenico et al., J. Invest. Derm., 102(5), pp. 676-680, May 1994.
Schiltz et al., J. Invest. Derm., 87(5), pp. 663-667, Nov. 1986.
Standeven et al., Toxicol. & Appl. Pharm., 138(1), pp. 169-175, May 1996.
Biochem. Biophys. Res. Commun., vol. 186, No. 2, pp. 977-983, 1992.
Biochem. Biophys. Res. Commun., vol. 179, No. 3, pp. 1554-1561, 1991.
Analytical Biochemistry, 1988, vol. 171, No. 2, pp. 238-247.
Genes Dev., 1994, vol. 8, No. 24, pp. 3068-3079.

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