Process for identification of substances modulating ureI depende

Details Process for identification of substances modulating ureI depende Process for identification of substances modulating ureI depende

1998-07-31

1999-08-24

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 12, 435 29, 435 4, C12Q 118, C12Q 158, C12Q 102, C12Q 100

Patent

active

059424095

ABSTRACT:
The present invention provides a screening process for the identification of anti-helicobactericidal substances modulating ureI dependent mechanisms of gastric Helicobacter metabolism. Gastric Helicobacter cells are treated with a substance to be tested for modulating ureI dependent mechanisms of gastric Helicobacter metabolism and gastric Helicobacter acid resistance or sensitivity to urea is determined.

REFERENCES:
patent: 4882271 (1989-11-01), Evans et al.
patent: 5556760 (1996-09-01), Nakamura et al.
patent: 5702911 (1997-12-01), Whalen
patent: 5804549 (1998-09-01), Blackburn et al.
Skouloubris et al., Infection and Immunity, "The Helicobacter pylori Urel Protein Is Not Involved in Urease Activity by Is Essential for Bacterial Survival In Vivo", Sep. 1998, pp. 4517-4521.

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