Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline d

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260268R, 260268CN, 260268C, 260268FT, 260564R, 260568, C07D23908

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active

039352137

ABSTRACT:
6,7-Dimethoxy-4-amino-2-(4-substituted piperazin-1-yl)-quinazolines and 6,7,8-trimethoxy-4-amino-2-(4-substituted piperazin-1-yl)quinazolines are produced by either: (1) reaction of the appropriate 4,5-dimethoxy substituted or 3,4,5-trimethoxy substituted 2-aminobenzonitrile with certain 1,4-disubstituted piperazines; or (2) reaction of the appropriate 4,5-dimethoxy substituted or 3,4,5-trimethoxy substituted 2-aminobenzamidine with the same 1,4-disubstituted piperazines. The products are known hypotensive agents.

REFERENCES:
patent: 3511836 (1970-05-01), Hess

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