Process for high throughput screening of CpG-based...

Details Process for high throughput screening of CpG-based... Process for high throughput screening of CpG-based...

2005-03-18

2010-10-26

Sajjadi, Fereydoun G (Department: 1633)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007800, C530S350000

Reexamination Certificate

active

07820379

ABSTRACT:
The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.

REFERENCES:
patent: 5567604 (1996-10-01), Rando et al.
patent: 5663153 (1997-09-01), Hutcherson et al.
patent: 5723335 (1998-03-01), Hutcherson et al.
patent: 6013639 (2000-01-01), Peyman et al.
patent: 6121434 (2000-09-01), Peyman et al.
patent: 6194388 (2001-02-01), Krieg et al.
patent: 6207646 (2001-03-01), Krieg et al.
patent: 6214806 (2001-04-01), Krieg et al.
patent: 6218371 (2001-04-01), Krieg et al.
patent: 6221882 (2001-04-01), Macfarlane
patent: 6239116 (2001-05-01), Krieg et al.
patent: 6339068 (2002-01-01), Krieg et al.
patent: 6339630 (2002-06-01), Macfarlane
patent: 6406705 (2002-06-01), Davis et al.
patent: 6429199 (2002-08-01), Krieg et al.
patent: 6479504 (2002-11-01), Macfarlane et al.
patent: 6521637 (2003-02-01), Macfarlane
patent: 6653292 (2003-11-01), Krieg et al.
patent: 6727230 (2004-04-01), Hutcherson et al.
patent: 6821957 (2004-11-01), Krieg et al.
patent: 6943240 (2005-09-01), Bauer et al.
patent: 6949520 (2005-09-01), Hartmann et al.
patent: 2001/0044416 (2001-11-01), Davis et al.
patent: 2002/0064515 (2002-05-01), Krieg et al.
patent: 2002/0091097 (2002-07-01), Bratzler et al.
patent: 2002/0164341 (2002-11-01), Davis et al.
patent: 2002/0165178 (2002-11-01), Schetter et al.
patent: 2003/0026801 (2003-02-01), Weiner et al.
patent: 2003/0050261 (2003-03-01), Krieg et al.
patent: 2003/0050263 (2003-03-01), Krieg et al.
patent: 2003/0050268 (2003-03-01), Krieg et al.
patent: 2003/0055014 (2003-03-01), Bratzler
patent: 2003/0067902 (2003-04-01), Bratzler et al.
patent: 2003/0091599 (2003-05-01), Davis et al.
patent: 2003/0100527 (2003-05-01), Krieg et al.
patent: 2003/0104523 (2003-06-01), Lipford et al.
patent: 2003/0139364 (2003-07-01), Krieg et al.
patent: 2003/0148316 (2003-08-01), Lipford et al.
patent: 2003/0148976 (2003-08-01), Krieg et al.
patent: 2003/0166001 (2003-09-01), Lipford
patent: 2003/0181406 (2003-09-01), Schetter et al.
patent: 2003/0191079 (2003-10-01), Krieg et al.
patent: 2003/0212026 (2003-11-01), Krieg et al.
patent: 2003/0224010 (2003-12-01), Davis et al.
patent: 2003/0232074 (2003-12-01), Lipford et al.
patent: 2003/0232856 (2003-12-01), MacFarlane
patent: 2004/0009949 (2004-01-01), Krieg
patent: 2004/0030118 (2004-02-01), Wagner et al.
patent: 2004/0053880 (2004-03-01), Krieg
patent: 2004/0067902 (2004-04-01), Bratzler et al.
patent: 2004/0067905 (2004-04-01), Krieg
patent: 2004/0087534 (2004-05-01), Krieg et al.
patent: 2004/0087538 (2004-05-01), Krieg et al.
patent: 2004/0092472 (2004-05-01), Krieg
patent: 2004/0106568 (2004-06-01), Krieg et al.
patent: 2004/0131628 (2004-07-01), Bratzler et al.
patent: 2004/0132685 (2004-07-01), Krieg et al.
patent: 2004/0142469 (2004-07-01), Krieg et al.
patent: 2004/0143112 (2004-07-01), Krieg
patent: 2004/0147468 (2004-07-01), Krieg et al.
patent: 2004/0152649 (2004-08-01), Krieg
patent: 2004/0152656 (2004-08-01), Krieg et al.
patent: 2004/0152657 (2004-08-01), Krieg et al.
patent: 2004/0162258 (2004-08-01), Krieg et al.
patent: 2004/0162262 (2004-08-01), Krieg et al.
patent: 2004/0167089 (2004-08-01), Krieg et al.
patent: 2004/0171150 (2004-09-01), Krieg et al.
patent: 2004/0171571 (2004-09-01), Krieg et al.
patent: 2004/0181045 (2004-09-01), Krieg et al.
patent: 2004/0198680 (2004-10-01), Krieg
patent: 2004/0198688 (2004-10-01), Krieg et al.
patent: 2004/0229835 (2004-11-01), Krieg et al.
patent: 2004/0234512 (2004-11-01), Wagner et al.
patent: 2004/0235770 (2004-11-01), McCluskie et al.
patent: 2004/0235774 (2004-11-01), Bratzler et al.
patent: 2004/0235777 (2004-11-01), Wagner et al.
patent: 2004/0235778 (2004-11-01), Wagner et al.
patent: 2004/0266719 (2004-12-01), McCluskie et al.
patent: 2005/0004061 (2005-01-01), Krieg et al.
patent: 2005/0004062 (2005-01-01), Krieg et al.
patent: 2005/0009774 (2005-01-01), Krieg et al.
patent: 2005/0032734 (2005-02-01), Davis et al.
patent: 2005/0032736 (2005-02-01), Krieg et al.
patent: 2005/0037403 (2005-02-01), Krieg et al.
patent: 2005/0037985 (2005-02-01), Krieg et al.
patent: 2005/0043529 (2005-02-01), Davis et al.
patent: 2005/0049215 (2005-03-01), Krieg et al.
patent: 2005/0049216 (2005-03-01), Krieg et al.
patent: 2005/0054601 (2005-03-01), Wagner et al.
patent: 2005/0054602 (2005-03-01), Krieg et al.
patent: 2005/0059619 (2005-03-01), Krieg et al.
patent: 2005/0059625 (2005-03-01), Krieg et al.
patent: 2005/0070491 (2005-03-01), Krieg et al.
patent: 2005/0075302 (2005-04-01), Hutcherson et al.
patent: 2005/0100983 (2005-05-01), Bauer et al.
patent: 2005/0101554 (2005-05-01), Krieg et al.
patent: 2005/0101557 (2005-05-01), Krieg et al.
patent: 2005/0119273 (2005-06-01), Lipford et al.
patent: 2005/0123523 (2005-06-01), Krieg et al.
patent: 2005/0130911 (2005-06-01), Uhlmann et al.
patent: 2005/0148537 (2005-07-01), Krieg et al.
patent: 2005/0169888 (2005-08-01), Hartman et al.
patent: 2005/0171047 (2005-08-01), Krieg et al.
patent: 2005/0181422 (2005-08-01), Bauer et al.
patent: 2005/0182017 (2005-08-01), Krieg
patent: 2005/0197314 (2005-09-01), Krieg et al.
patent: 2005/0215500 (2005-09-01), Krieg et al.
patent: 2005/0215501 (2005-09-01), Lipford et al.
patent: 2005/0233995 (2005-10-01), Krieg et al.
patent: 2005/0233999 (2005-10-01), Krieg et al.
patent: 2005/0239732 (2005-10-01), Krieg et al.
patent: 2005/0239733 (2005-10-01), Jurk et al.
patent: 2005/0239734 (2005-10-01), Uhlmann et al.
patent: 2005/0239736 (2005-10-01), Krieg et al.
patent: 2005/0244379 (2005-11-01), Krieg et al.
patent: 2005/0244380 (2005-11-01), Krieg et al.
patent: 2005/0245477 (2005-11-01), Krieg et al.
patent: 2005/0250726 (2005-11-01), Krieg et al.
patent: 2005/0256073 (2005-11-01), Lipford et al.
patent: 2005/0267057 (2005-12-01), Krieg
patent: 2005/0267064 (2005-12-01), Krieg et al.
patent: 2005/0277604 (2005-12-01), Krieg et al.
patent: 2005/0277609 (2005-12-01), Krieg et al.
patent: 2006/0003955 (2006-01-01), Krieg et al.
patent: 2006/0003962 (2006-01-01), Ahluwalia et al.
patent: 2006/0019916 (2006-01-01), Krieg et al.
patent: 2006/0019923 (2006-01-01), Davis et al.
patent: 1142472 (2001-10-01), None
patent: WO94/29469 (1994-12-01), None
patent: WO96/2555 (1996-02-01), None
patent: WO96/24380 (1996-08-01), None
patent: WO97/00957 (1997-01-01), None
patent: WO98/18810 (1998-05-01), None
patent: WO98/29430 (1998-07-01), None
patent: WO98/32462 (1998-07-01), None
patent: WO98/37919 (1998-09-01), None
patent: WO98/40100 (1998-09-01), None
patent: WO98/50547 (1998-11-01), None
patent: WO98/52581 (1998-11-01), None
patent: WO99/20756 (1999-04-01), None
patent: WO99/51259 (1999-10-01), None
patent: WO99/56755 (1999-11-01), None
patent: WO99/58118 (1999-11-01), None
patent: WO99/61056 (1999-12-01), None
patent: WO00/06588 (2000-02-01), None
patent: WO00/14217 (2000-03-01), None
patent: WO00/67023 (2000-11-01), None
patent: WO01/22972 (2001-04-01), None
patent: WO01/22990 (2001-04-01), None
patent: WO01/32877 (2001-05-01), None
patent: WO01/55386 (2001-08-01), None
patent: WO02/06936 (2002-09-01), None
patent: WO03/03569 (2003-01-01), None
patent: WO03/04357 (2003-05-01)

Affiliated with

Also associated with

Rating

Process for high throughput screening of CpG-based... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for high throughput screening of CpG-based..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for high throughput screening of CpG-based... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4212780