Process for heat treatment of aqueous solution containing human

Details Process for heat treatment of aqueous solution containing human Process for heat treatment of aqueous solution containing human

1982-02-19

1984-05-01

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112B, A61K 3514

Patent

active

044461348

ABSTRACT:
Human blood coagulation factor VIII which may have hepatitis virus activity can be virus-inactivated with keeping at a minimum the damage of the factor VIII by heating its aqueous solution at 50.degree. to 80.degree. C. for 3 to 15 hours in the presence of 10% (W/V) or more of at least one principal stabilizer of neutral amino acids, monosaccharides, oligosaccharides, and sugar alcohols and 10% (W/V) or more of at least one auxiliary stabilizer of salts of hydrocarbon and hydroxyhydrocarbon carboxylic acids having 3 to 10 carbon atoms.

REFERENCES:
patent: 2705230 (1955-03-01), Reid
patent: 4085095 (1978-04-01), Bick
patent: 4297344 (1981-10-01), Schwinn
patent: 4327086 (1982-04-01), Fukushima
Barrow, Chem. Abs., vol. 81, 1974, Ab No. 134384j.
Barrow, Chem. Abs., vol. 76, 1972, Ab No. 150146k.
Hynes, Chem. Abs., vol. 72, 1970, Ab No. 52736a.
Vlckova, Chem. Abs., vol. 74, 1971, Ab No. 10185j.

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