Process for heat treatment of aqueous solution containing cold i

Details Process for heat treatment of aqueous solution containing cold i Process for heat treatment of aqueous solution containing cold i

1982-02-22

1984-01-03

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424177, 260112B, A61K 3514, A61K 3700

Patent

active

044242069

ABSTRACT:
Cold insoluble globulin which may have hepatitis virus activity can be virus-inactivated with keeping at a minimum the damage of the cold insoluble globulin by heating its aqueous solution at 50.degree. to 80.degree. C. for 5 to 20 hours in the presence of 10% (W/V) or more of at least one principal stabilizer of neutral amino acids, monosaccharides, disaccharides, and sugar alcohols with or without 10% (W/V) or more of at least one auxiliary stabilizer of salts of hydrocarbon carboxylic acids or hydroxyhydrocarbon carboxylic acids both having 3 to 10 carbon atoms.

REFERENCES:
patent: 4305871 (1981-12-01), Shanbrom
patent: 4327086 (1982-04-01), Fukushima et al.
Shikata et al.-J. of Infect. Dis., vol. 138, No. 2 (Aug. 1978), p. 242.

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