Process for heat treating chemically unmodified gamma-globulin

Details Process for heat treating chemically unmodified gamma-globulin Process for heat treating chemically unmodified gamma-globulin

1987-07-09

1989-07-04

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

424 858, 424101, 514 8, 530830, A61K 39395

Patent

active

048451991

ABSTRACT:
A process for heat treating an aqueous solution containing chemically unmodified .gamma.-globulin, wherein said heat treating is carried out in the presence of sorbitol is disclosed. By the heat treatment, impurity viruses can be inactivated without causing impairment of activities of chemically unmodified .gamma.-globulin, increasing polymer contents or increasing an anticomplement titer.

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patent: 4374763 (1983-02-01), Takagi
patent: 4396608 (1983-08-01), Tenold
patent: 4412990 (1983-11-01), Lundblad et al.
patent: 4424206 (1984-01-01), Ohmura et al.
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patent: 4440679 (1984-04-01), Fernandes et al.
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patent: 4478829 (1984-10-01), Landaburu et al.
patent: 4579735 (1986-04-01), Heimburger et al.
patent: 4623717 (1986-11-01), Fernandes et al.
patent: 4721777 (1988-01-01), Uemura et al.
The Lancet, Nov., 1983, 1198-1199, Welch et al.

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