Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1979-09-19
1981-09-01
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
424 95, 260112R, A61K 3537, A61K 3700
Patent
active
042871840
ABSTRACT:
Healing of a wound is accelerated by administering a new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions. The nerve growth factor is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The pure nerve growth factor is obtained by subjecting the component rich in nerve growth factor to at least one additional chromatography step, usually two to four, to recover pure nerve growth factor having a molecular weight of about 116,000. The nerve growth factor is applied directly to the wound.
REFERENCES:
Varon, et al,; Biochemistry, 6, No. 7, 1967, pp. 2202-2209.
Young, et al.; Biochemistry, 17, No. 8, 1978, pp. 1490-1498.
Greene, et al.; Biochemistry, 8, No. 9, 1969, pp. 3735-3741.
Smith, et al.; Biochemistry, 8, No. 12, 1969, pp. 4918-4926.
Baker, Jour. of Biological Chem., 250, No. 5, 1975, pp. 1714-1717.
Pantazis, et al., Biochemistry, 16, 1977, pp. 1525-1530.
Konovalov, et al., Tsitologiya, 16, No. 10, 1974, pp. 1268-1274 (full translation submitted in Ser. No. 854,144 considered).
Brust Joseph Paul
Cook Paul J.
Guthrie Marvin C.
The Massachusetts General Hospital
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