Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Reexamination Certificate
2007-09-12
2010-12-07
Lilling, Herbert J. (Department: 1657)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
C435S254700, C435S256500
Reexamination Certificate
active
07846699
ABSTRACT:
The present invention provides an improved process for the production of gibberellic acid (GA3), achieving a yield over 225 g/kg of GA3with solid substrate fermentation, and over 15 g/L by submerged fermentation. The method also provides novel substrates, including the use of Jatropha seed cake. The present invention has in particular provided an improved, cost-effective process for the manufacture of GA3, as the process has a surprisingly high yield of product, achieves the maximal yield in shorter time than other techniques, consumes less energy, and works with very inexpensive substrates. In all, the manufacturing costs are significantly reduced.
REFERENCES:
patent: 2842051 (1958-07-01), Brian et al.
patent: 2865812 (1958-12-01), Borrow et al.
patent: 2906670 (1959-09-01), Borrow et al.
patent: 2906671 (1959-09-01), Borrow et al.
patent: 2906673 (1959-09-01), Borrow et al.
patent: 3021261 (1962-02-01), Bergman et al.
Agosin et al, “Production of gibberellins by soild substrate cultivation ofGibberella fujikuroi”, edited by Roussous et al, Advances in Solid State Fermentation, 1997, 355-366.
Bandelier et al., “Production of gibberellic acid by fed-batch solid state fermentation in an aseptic pilot-scale reactor”, Process Biochemistry, 1997, 32(2):141-145.
Berrios et al., “Spectrophotometric method for determining gibberellic acid in fermentation broths”, Biotechnology Letters, 2004, 26: 67-70.
Escamilla et al., “Optimization of gibberellic acid production by immobilizedGibberella fujikuroimycelium in fluidized bioreactors”, Journal of Biotechnology, 2000, 76: 147-155.
Ergun et al., “Auxin (Indole-3-acetic acid), Gibberellic acid (GA3), abscisic acid (ABA) and cytokinin (Zeatin) production by some species of Mosses and Lichens”, Turk J Bot., 2002, 26: 13-18.
Gelmi et al., “Solid substrate cultivation ofGibberella fujikuroion an inert support”; Process Biochemistry. 2000, 35:1227-1233.
Jefferys, E.G., “The Gibberellin Fermentation”, Adv. Appl. Biol. 1970, 13:283-315.
Kumar et al., “Microbial production of Gibberellins:state of the art,” Adv. Appl. Microbiol., 1989, 34: 29-139.
Kumar et al., “Potential of fed-batch culture in solid state fermentation for production of gibberilic acid”, Biotechnology Letters, 1987, 9(3): 179-182.
Kumar et al., “Batch and fed-batch solid-state fermentations: kinetics of cell growth, hydrolytic enzymes productin, and gibberellic acid production”, Process Biochemistry, 1988, 23: 43-47.
Kumar et al., “Solid state fermentation : physical and nutritional factors influencing gibberellic acid production”, Appl. Microbiol. Biotechnol. 1990, 34: 145-148.
Machado et al., “Kinetics ofGibberella fujikuroigrowth and gibberellic acid production by solid-state fermentation in a packed-bed column bioreactor”, Biotechnol. Prog., 2004, 20:1449-1453.
Booth, C., “TheFusariumproblem: historical, economic and taxonomic aspects”, in “The applied mycology ofFusarium”, edited by Moss et al., Cambridge University Press, 1982, 1-12.
Pastrana et al., “Interactions affecting gibberellic acid production in solid-state culture: A factorial study”, Enzyme and Microbial Technology, 1995, 17:784-790.
Prema et al., “Production of gibberellie acid by solid state fermentation: potential and feasibility.”, Indian J. Microbiol., 1988, 28:1-2.
Puchooa et al., “A study on the use of carrot juice in the tissue culture ofDaucus carota”, African Journal of Biotechnology, 2004, 3(4): 248-252.
Qian et al, “Factors affecting gibberellic acid production byFusarium moniliformein solid-state cultivation on starch”, World Journal of Microbiology & Biotechnology, 1994, 10:93-99.
Sharma et al. “Determination of gibberellins in fermentation broth produced byFusarium verticilliodesMTCC 156 by high-performance liquid chromatography tandem mass spectrometry”, Biotechnol. Appl. Biochem., 2004, 39, 83-88.
Tudzynski “Biosynthesis of gibberellins inGibberella fujikuroi: biomolecular aspects”, Appl. Microbiol. Biotechonol, 1999, 52: 298-310.
Balu Guduri
Rangaswamy Vidhya
Foley & Lardner LLP
Lilling Herbert J.
Reliance Life Sciences Pvt. Ltd.
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