Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-11-10
1997-01-14
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352401, C12P 2106, C12N 500
Patent
active
055938647
ABSTRACT:
DNAs encoding voltage-activated cation channels have been cloned and characterized. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells.
REFERENCES:
Hall and Kasbekar, Drosophila Sodium Channel Mutations Affect Pyrethroid Sensitivity, University of New York at Buffalo, pp. 99-114.
Noda, Masaharu et al., Existence of distinct sodium channel messenger RNAs in rat brain, Nature, vol. 320, pp. 188-192 (1986).
Liman, E., et al., Subunit Stoichiometry of a Mammalian K+ Channel Determined by Construction of Multimeric cDNAs, Neuron, vol. 9, pp. 861-871 (1992).
Jackson, F., et al., The tip-E Mutation of Drosophila Decreases Saxitoxin Binding and Interacts with Other Mutations Affecting Nerve Membrane Excitability, Journ. of Neurogenetics, 3, pp. 1-17 (1986).
Taylor, Martin F. J. et al., Linkage of Pyrethroid Insecticide Resistance to a Sodium Channel Locus in the Tobacco Budworm, Insect Biochem. Molec. Biol., vol. 23, No. 7, pp. 763-775, (1993).
Knipple, D. C., et al., Tight genetic linkage between the kdr insecticide resistance trait and a voltage-sensitive sodium channel gene in the house fly, Proc. Natl. Acad. Sci., vol. 91, pp. 2483-2487 (1994).
Williamson, M., et al., Knockdown resistance (kdr) to DDT and pyretroid insecticides maps to a sodium channel gene locus in the housefly (Musca domestica), Mol. Gen. Genet. 240: pp. 17-22 (1993).
Hall, L. M. et al., Molecular and genetic analysis of tip-E: a mutation affecting sodium channels in Drosphila, 35th Annual Drosphila Res. Conf., Program & Absts. vol, p. 77. (1994).
Hall & Feng, Abstracts of papers presented at the 48th Annual mfg. of the society of general physiologists, Marine Biological Lab, The tip-E Locus Defines a Novel Membrane Protein Required During Development to Rescue Adult Paralysis, p. 11a, (1994).
O'Dowd and Aldrich, Voltage-Clamp Analysis of Sodium Channels in Wild-type and Mutant Drosophila Neurons, The Journal of Neuroscience, 8 (10), pp. 3633-3643 (1988).
Barry Ganetzky Neurogenetic Analysis of Drosophila Mutations Affecting Sodium Channels: Synergistic Effects on Viability and Nerve Conduction in Double Mutants Involving tip-E, Journal of Neurogenetics, 3, pp. 19-31 (1986).
Thackeray and Ganetzky, Developmentally Regulated Alternative Splicing Generates a Complex Array of Drosophila para Sodium Channel Isoforms, The Journal of Neuroscience, 14 (5), pp. 2569-2578 (1994).
Loughney, K., et al., Molecular Analysis of the para Locus, a Sodium Channel Gene in Drosophila, Cell, vol. 58, pp. 1143-1154 (1989).
Ramaswami and Tanouye, Two sodium-channel genes in Drosophila: Implications for channel diversity, Proc. Natl. Acad. Sci., vol. 86, pp. 2079-2082 (1989).
Salkoff, L., et al., Genomic Organization and Deduced Amino Acid Sequence of a Putative Sodium Channel Gene in Drosophila, Science, vol. 237, pp. 744-749 (1987).
Gordon, D., et al., Biochemical Characterization of Insect Neuronal Sodium Channels, Archives of Insect Biochemistry and Physiology 22; pp. 41-53 (1993).
William A. Catterall, Cellular and Molecular Biology of Voltage-Gated Sodium Channels, Physiological Reviews, vol. 72, No. 4 (Suppl.) pp. S15-S48 (1992).
Thummel, C. et al., Vectors for Drosophila P-element-mediated transformation and tissue culture transfection, Gene, 74, pp. 445-456 (1988).
Bunch, T., et al., Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells, Nucleic Acids Research, vol. 16, No. 3, pp. 1043-1059 (1988).
Noda, M., et al., Primary Structure of Electrophorus Electricus Sodium Channel Deduced from cDNA Sequence, Nature, vol. 312, 8, pp. 121-127 (1984).
Stevens, Charles, And now the sodium channel, Nature, vol. 312 pp. 98-99 (1984).
Goldin et al., "Messenger RNA coding for only the alpha-subunit of the rat brain NA channel is sufficient for expression of functional channels in Xenopus oocytes", Proc. Natl. Acad. Sci, vol. 83, pp. 7503-7507, Oct. 1986.
Noda et al., "Expression of functional sodium channels from cloned cDNA", Nature, vol. 322, pp. 826-829 (1986).
Casadei et al, "Immunoaffinity Isolation of Na+ Channels from Rat Skeletal Muscle", Jour. Biol. Chem. vol. 261, No. 9, pp. 4318-4323 (1986).
Oh et al. "Single channel characteristics of a purified bovine renal ailoride-sensitive Na+ channel in planar lipid bilayers", Am. Jour. Phys. vol. 264, No. 6, No. 6, pp. 1489-1499 (1993).
Amichot et al. "Transcription Analysis of the para Gene by In situ Hybridization and Immunological Characterization of its Expression Product in Wild-type and Mutant Strains of Drosophila", Insect Biochem. & Mole. Biol. vol. 23, No. 3, pp. 381-390 (1993).
Schreibmayer et al. "Mechanism of modulation of single sodium channels from skeletal muscle by the beta-1 subunit from rat brain", Pfluegers Archiv. Europ. Jour. Phys. vol. 426, Nos. 3-4 pp. 360-362 (1994).
Feng et al., "Cloning and Functional Analysis of TipE, a Novel Membrane Protein that Enhances Drosophila para Sodium Channel Function", Cell, vol. 82, No. 6 pp. 1001-1011 (1995).
Krafte et al. (1990) J. Gen. Physiol. 96: 689-706.
Catterall (1986) Ann. Rev. Biochem. 55:953-985.
Dascal et al. (1986) Science 231: 1147-1150.
Gil et al. (1989) Soc. Neurosci. Ann. Mtg. Abstr. 14(2): 835.
Feng et al. (1993) Soc. Neurosci. Ann. Mtg. Abst. 19:284.
Feng et al. (1995) Genetics 139: 1679-1688.
Hall et al. (1992) Soc. Neurosci. Ann. Mtg. Abst. 18(2): 1134.
Hall et al. (1995) Soc. Neurosci. Ann. Mtg. Abstr. 21: 1823.
Isom et al. (1992) Science 256: 839-841.
Tomaselli et al. (1989) J. Clin. Invest. 83: 1724-1732.
Arena Joseph P.
Feng Guoping
Hall Linda M.
Liu Ken
Van Der Ploeg Leonardus H. T.
Hand J. Mark
Hobbs Lisa J.
Merck & Co. , Inc.
The Research Foundation of State University of New York
Tribble Jack L.
LandOfFree
Process for functional expression of the para cation channel does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for functional expression of the para cation channel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for functional expression of the para cation channel will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1387469