Process for fractionating polyethylene glycol (PEG)-protein addu

Details Process for fractionating polyethylene glycol (PEG)-protein addu Process for fractionating polyethylene glycol (PEG)-protein addu

1995-04-14

1999-03-09

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

424 851, 424 943, 4241791, 435188, 514 3, 514 21, 530345, 530351, 5303919, 530408, 530410, C07K 1113, C07K 19535, C07K 1462, C12N 996

Patent

active

058802550

ABSTRACT:
The invention relates to fractionating a mixture of polyethylene glycol (PEG)-protein adducts having different degrees of PEG substitution by partitioning the PEG-protein adducts in a PEG-containing aqueous biphasic system according to the degree of PEG substitution. A new PEG-gm-CSF obtained by the process is useful in pharmaceutical compositions for use in therapeutic or diagnostic methods.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4415665 (1983-11-01), Mosbadu et al.
patent: 4740304 (1988-04-01), Tjerneld et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4904584 (1990-02-01), Shaw
patent: 5093531 (1992-03-01), Sano et al.
patent: 5166322 (1992-11-01), Shaw et al.
patent: 5349052 (1994-09-01), Delgado et al.
Chaabouni et al., "Affinity Partition of Proteins in Aqueous Two-Phase Systems Containing Polyoxyethylene Glycol-Bound Ligand sand Charged Dextrans" Chemical Abstracts, 90(21), (21 May 1979) Abstract No. 164184x.
Karr et al., "Cell Separation by Immunoaffinity Partitioning With Polyethylene Glycol-Modified Protein A in Aqueous Polymer Two-Phase Systems" (1988) J. Chromatography 442:219-227.
Abuchowski et al., "Effect of Covalent Attachment of Polyethylene Glycol on Immunogenicity and Circulating Life of Bovine Liver Catalase," (1977) J. Bio. Chem. 252(11):3582-3586.

Affiliated with

Also associated with

Rating

Process for fractionating polyethylene glycol (PEG)-protein addu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for fractionating polyethylene glycol (PEG)-protein addu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for fractionating polyethylene glycol (PEG)-protein addu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1322394