Process for fractionating phosphatide mixtures

Details Process for fractionating phosphatide mixtures Process for fractionating phosphatide mixtures

1991-11-19

1993-05-25

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

558146, 558150, C07F 910

Patent

active

052141713

ABSTRACT:
Process for fractionating phosphatide mixtures into two or more fractions which are enriched in one or more of phosphatidyl choline (PC), phosphatidyl ethanolamine (PE), phosphatidyl inositol (PI) and phosphatidic acid (PA) by carrying out extraction steps using alcoholic solvent in which the solubilities of PC, PE and PA are controlled by suitably adjusting the acidity of the solvent, the pH being adjusted to above 8 for solubilizing PC and PE and to below 5 for solubilizing PA. PI is substantially insoluble in the solvent used in the process and thus is mainly recovered in the extraction residue. Further parameters influencing the solubility of the components of the phosphatide mixtures to be fractionated are water content of the alcoholic solvent, temperature and choice of bases and acids for adjusting the pH. For further separating fractions rich in PC and PE di- or trivalent metal salt solutions are used.

REFERENCES:
patent: 2724649 (1955-11-01), Julian et al.
patent: 3739047 (1973-06-01), Stanford et al.
patent: 4235793 (1980-11-01), Betzing
patent: 4425276 (1984-01-01), Gunther
patent: 4698185 (1987-10-01), Dijkstra et al.
Shchipunov et al., Chemical Abstracts, vol. 100, 1984, Abstract 1454512.

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