Plastic and nonmetallic article shaping or treating: processes – Encapsulating normally liquid material – Liquid encapsulation utilizing an emulsion or dispersion to...
Patent
1988-07-25
1990-06-12
Lovering, Richard D.
Plastic and nonmetallic article shaping or treating: processes
Encapsulating normally liquid material
Liquid encapsulation utilizing an emulsion or dispersion to...
264 41, 264 46, 424 943, 424450, 425 5, 436829, A61K 966, A61K 3722, A61K 3748, B01J 1302
Patent
active
049331213
ABSTRACT:
The present invention relates to a process for forming stable, uniform unilamellar or oligolamellar liposomes which encapsulate a macromolecule. However, unlike prior processes, the present method maintains a temperature below the phase transition temperature of the lipid used to make the liposome both during the hydration of the lipid and, if used, during an extrusion step. In addition, the liposome is formed and the macromolecule encapsulated in a low ionic strength solution, then they are dialyzed against a high ionic strength solution.
REFERENCES:
patent: 4263428 (1981-04-01), Apple et al.
patent: 4448765 (1984-05-01), Ash et al.
patent: 4529561 (1985-07-01), Hunt et al.
patent: 4564599 (1986-01-01), Janoff et al.
patent: 4605630 (1986-08-01), Kung et al.
patent: 4619795 (1986-10-01), Cohen
Szoka, Jr. et al.: "Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)", Ann. Rev. Biophys. Bioeng. 9: 467-508 (1980).
Law Say-Jong
Piran Uri
Ciba Corning Diagnostics Corp.
Gosz William G.
Lovering Richard D.
Slepchuk Nicholas I.
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