Process for forming liposomes

Details Process for forming liposomes Process for forming liposomes

1988-07-25

1990-06-12

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 41, 264 46, 424 943, 424450, 425 5, 436829, A61K 966, A61K 3722, A61K 3748, B01J 1302

Patent

active

049331213

ABSTRACT:
The present invention relates to a process for forming stable, uniform unilamellar or oligolamellar liposomes which encapsulate a macromolecule. However, unlike prior processes, the present method maintains a temperature below the phase transition temperature of the lipid used to make the liposome both during the hydration of the lipid and, if used, during an extrusion step. In addition, the liposome is formed and the macromolecule encapsulated in a low ionic strength solution, then they are dialyzed against a high ionic strength solution.

REFERENCES:
patent: 4263428 (1981-04-01), Apple et al.
patent: 4448765 (1984-05-01), Ash et al.
patent: 4529561 (1985-07-01), Hunt et al.
patent: 4564599 (1986-01-01), Janoff et al.
patent: 4605630 (1986-08-01), Kung et al.
patent: 4619795 (1986-10-01), Cohen
Szoka, Jr. et al.: "Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)", Ann. Rev. Biophys. Bioeng. 9: 467-508 (1980).

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