Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-08-14
1994-02-08
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352541, 424 93Q, C12P 1718, C12N 114, A01N 6300, A61K 3700
Patent
active
052847586
ABSTRACT:
This invention relates to a fungal microorganism Pseudodiplodia sp. (MF5767) isolated from bark discs of Hibiscus sp. and useful in a fermentation process to form compounds of formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
REFERENCES:
patent: 5026554 (1991-06-01), Bartizal et al.
patent: 5053425 (1991-10-01), Bartizal et al.
patent: 5096923 (1992-03-01), Bergstrom
patent: 5102907 (1992-04-01), Bergstrom et al.
Bills Gerald F.
Clapp Wendy H.
Omstead Mary N.
Pelaez Fernando
Dolan Catherine A.
Matukaitis Paul D.
Merck & Co. , Inc.
Robinson Douglas W.
Sevigny Jeffrey J.
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