Process for fluorination of uracil

Details Process for fluorination of uracil Process for fluorination of uracil

1977-04-29

1978-04-04

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D23954

Patent

active

040827526

ABSTRACT:
An improved process for fluorination of uracil, which comprises treating uracil with fluorine which is optionally diluted with an inert gas (e.g. nitrogen gas) at a temperature of -10.degree. to 15.degree. C in a 50 to 85% by weight aqueous solution of hydrofluoric acid as the reaction medium to form 5-fluorouracil, and optionally subjecting the reaction mixture to a heat treatment at a temperature higher than the reaction temperature, to give 5-fluorouracil in a high yield.

REFERENCES:
patent: 3682917 (1972-08-01), Knuniants et al.
patent: 3954758 (1976-05-01), Schuman et al.

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