Process for fluorinating uracil and derivatives thereof

Details Process for fluorinating uracil and derivatives thereof Process for fluorinating uracil and derivatives thereof

1971-10-04

1976-05-04

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260257, 424251, 424254, C07D23954, C07D23962

Patent

active

039547582

ABSTRACT:
Direct fluorination of uracil and its derivatives, in the presence of an aqueous solvent, by fluorine gas to produce 5-fluorouracil and 5-fluorouracil derivatives is disclosed. Novel compounds produced by the reaction, such as 5,5-difluoro-6-hydroxy-5,6-dihydrouracil are also disclosed. The derivatives of 5-fluorouracil are useful as germicidal agents while 5-fluorouracil itself is a known cancer chemotherapy agent.

REFERENCES:
patent: 3277092 (1966-10-01), Duschinsky et al.
patent: 3682917 (1972-08-01), Knuniants et al.
Wang, Journal of Organic Chemistry 24, 11-13 (1959).

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