Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compou

Details Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compou Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compou

1985-02-01

1988-05-10

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546270, 546275, 548217, 548222, 548224, 548229, 548237, 548239, 564 86, 564211, C07D26304, C07D10340

Patent

active

047437006

ABSTRACT:
Replacement with fluorine of the primary hydroxy group of 1-phenyl-2-amino-1,3-propanediol compounds wherein the secondary hydroxy group and the amino group have been suitably protected.
The reaction is carried out with an inorganic fluoride in a polyglycol.
New oxazoline compounds particularly useful in said process.

REFERENCES:
patent: 4235892 (1980-11-01), Nagabhushan
Jommi et al., Chem. Abst. 103-22574n.
Milos Hudlicky, Chemistry of Organic Flurine Compounds, pp. 112-113.
Chemistry and Industry, Feb. 8, 1958, p. 157-Ref. 87 (A) J.A.C.S., 77, 4899, (1955) "Synthesis of Alkyl and Substituted Alkyl Fluorides from p-Toluenesfulfonic Acid Esters, the Preparation of p-Toluenesulfonic Acid Esters of Lower Alcohols by Walter F. Edgell and L. Parts-Ref. 23 (B).
Can. J. Chem., 34, (1956) "The Preparation and Some Cleavage Reactions of Alkyl and Substituted Alkyl Methanesulphonates by F. L. M. Pattison and J. E. Millington Ref. 820 (C).
10-Organic Chemistry p. 6154-Ref. 869 (D).

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