Process for extractive fermentation

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-4-aza-bicyclo

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435101, 435144, 435161, 435813, 435822, 435911, 435917, 435935, 435942, 435102, 210634, 203 60, 203 61, 203 62, 203 63, 203 64, 203DIG13, C12P 3700, C12P 1904, C12P 748, C12P 706, B01D 1104, B01D 334

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048659738

ABSTRACT:
A process for producing a variety of chemical products, e.g., ethanol, by fermentation in which the product is removed from the fermentation medium as it is formed by liquid-liquid extraction using an extractant for the product which is immiscible with water. The extractant employed is chosen from the following groups: (A) double bond unsaturated aliphatic alcohols having 12 or more carbon atoms; (B) saturated branched chain aliphatic alcohols having 14 or more carbon atoms or mixtures thereof; (C) double bond unsaturated aliphatic acids having 12 or more carbon atoms; (D) aliphatic and aromatic mono-, di- or tri-esters having 12 or more carbon atoms, other than dibutyl phthalate; (E) aliphatic noncyclic ketones and aliphatic aldehydes having 12 or more carbon atoms; and (F) mixtures of extractants from groups (A) to (E) above or mixtures of at least one of the above extractants and at least one other extractant. These extractants are non-toxic to microorganisms used for fermentation, have little tendency to form emulsions and are otherwise suited for the process. The liquid-liquid extraction may thus be carried out in situ in the fermentor, preferably in a continuous stirred tank fermentor.

REFERENCES:
patent: 4517298 (1985-05-01), Tedder
patent: 4698303 (1987-10-01), Bailey et al.
Ishii et al.; J. Chem. Eng. of Japan, 18(2):125-130; (1985).
Taya et al., J. Ferment. Technol., 63(2):181-187; (1985).
Minier et al.; Biotech. & Bioeng.; 24:1565-1579; (1982).
Wang et al.; Biotech. & Bioeng. Symp., No. 11:555-565 (1981).

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