Chemistry: natural resins or derivatives; peptides or proteins; – Lignins or derivatives
Patent
1995-03-31
1998-01-06
Nutter, Nathan M.
Chemistry: natural resins or derivatives; peptides or proteins;
Lignins or derivatives
530507, 426430, 426479, 426482, 426484, 536 41, 536128, C07G 100, C08L 9700
Patent
active
057056188
ABSTRACT:
A process is described for extracting lignans from flaxseed which comprises contacting a substantially oil-free flaxseed meal with an aliphatic alcohol solvent, e.g. a mixture of methanol or ethanol with water, to extract lignans into the alcohol solvent and separating residual solids from the lignan-rich alcohol solvent. The lignan-rich alcohol solvent is concentrated by removing solvent therefrom and the lignan concentrate obtained is subjected to a base-catalyzed hydrolysis to liberate lignans therefrom in a non-complexed form. Thereafter, the hydrolyzed concentrate is subjected to either a liquid/liquid partition, e.g. by an ethyl acetate/water system, or anion exchange to further enrich the lignans and the lignan-enriched solution thus obtained is subjected to chromatographic separation to isolate lignans at a purity of greater than 90 percent. The lignan, secoisolariciresinol diglucoside, was found in amounts of up to 20 mg per gram of defatted flaxseed.
REFERENCES:
patent: 5169660 (1992-12-01), Collins et al.
patent: 5485595 (1996-01-01), Ikeya et al.
MacRae and Towers, "Biological Activities of Lignans", Phytochemistry, vol. 23, No. 6, pp. 1207-1220, 1984.
Bambagiotti-Alberti et al, "Revealing the Mammalian Lignan Precursor Secoisolariciresinol Diglucoside in Flax Seed by Ionspray Mass Spectrometry", Rapid Communications in Mass Spectrometry, vol. 8, 595-598 (1994).
Muir Alister D.
Westcott Neil D.
Agriculture and Agri-Food Canada
Nutter Nathan M.
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