Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1984-12-18
1987-03-03
Siegel, Alan
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
514 21, 514869, 530425, A61K 3534, C07K 114, C07K 1506
Patent
active
046474552
ABSTRACT:
Diuretic and natriuretic extracts, at least partially characterized as peptides, have been obtained by homogenization of mammalian heart atria with an aqueous solution of a lower carboxylic acid. After precipitation of impurities by pH adjustment, the extract may be further purified chromatographically. Extracts injected into text rats resulted in 30-40 fold increases in sodium and chloride excretions within 5-10 minutes of injection. Urine volume rose 10-15 fold and potassium excretion doubled. The response was complete in 20 minutes and no similar changes in renal function were observed following injection of a similarly obtained ventricular extract.
REFERENCES:
patent: 3822348 (1974-07-01), Higashi et al.
Bennett et al, Biochemistry 1981 20, 4530-4538.
deBold et al., J. Histochem. Cytochem. 1978, vol. 26, No. 12, pp. 1094-1102.
DeBold et al., Life Sciences vol. 28(1), 89-94, 1981 via Chem. Abstracts vol. 94 62919(f).
de Bold, Canadian Journal of Physiology and Pharmacology, vol. 60, No. 3, pp. 324-330 (1982).
Abstract No. 1846, Part 1 of 65th Annual Meeting of Federation of American Society for Experimental Biology, Atlanta, GA, Apr. 12-17, 1981.
Abstract Published Mar. 1, 1981, cited by Trippodo et al, as de Bold, Fed. Proc., vol. 40, p. 554 (Abstract), 1981.
Trippodo et al, Proceedings of the Society for Experimental Biology and Medicine, vol. 170, pp. 502-508, 1982.
Queen's University at Kingston
Siegel Alan
Stone Jacqueline M.
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