Process for exchanging functional groups by halogen-metal...

Details Process for exchanging functional groups by halogen-metal... Process for exchanging functional groups by halogen-metal...

2005-03-11

2008-10-21

Davis, Zinna N (Department: 1625)

Radiant energy

Ionic separation or analysis

Static field-type ion path-bending selecting means

C250S297000

Reexamination Certificate

active

07439535

ABSTRACT:
A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group.Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R1—Mg—X (I) (wherein R1represents a halogen atom or an optionally substituted hydrocarbon residue; and X1represents a halogen atom) and an organolithium compound represented by the formula R2—Li (II)(wherein R2represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.

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K. Oshima et al., “Use of Organomanganese Reagents in Organic Synthesis”, Journal of Organometallic Chemistry, vol. 575, No. 1, pp. 1-20, Feb. 22, 1999.
L. Boymond et al., “Preparation of Highly Functionalized Gringnard Reagents by an Iodine-Magnesium Exchange Reaction and its Application in Solid-Phase Synthesis”, Angew. Chem. Int. Ed., vol. 37, No. 12, pp. 1701-1703, Dec. 17, 1998.

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