Process for enzyme inhibitors

Details Process for enzyme inhibitors Process for enzyme inhibitors

1982-08-19

1983-09-13

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435121, 435886, C12P 1712, C12P 1710, C12R 1465

Patent

active

044042817

ABSTRACT:
Angiotensin I converting enzyme inhibitor A-58365 factor A is produced in enhanced yields by culturing Streptomyces chromofuscus NRRL 15098 under submerged aerobic fermentation conditions in a proline supplemented aqueous nutrient culture medium containing assimilable sources of carbon, nitrogen and inorganic salts.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4154935 (1979-05-01), Ondetti et al.
patent: 4226879 (1980-10-01), Omura et al.
patent: 4316905 (1982-02-01), Krapcho
patent: 4316906 (1982-02-01), Ondetti et al.
Cushman, D. W. et al., Federation Proceedings, vol. 38, No. 13, Dec. 1979.
Derwent abstract 25836D/15 of EP25-941.
A. A. Patchett et al., Nature, 288:280-283, 1980.

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